Pharmacologic Advantages of Antiepileptic Drug Monotherapy
نویسندگان
چکیده
منابع مشابه
Antiepileptic Drug Monotherapy: The Initial Approach in Epilepsy Management
Antiepileptic drug (AED) monotherapy is the preferred initial management approach in epilepsy care, since most patients may be successfully managed with the first or second monotherapy utilized. This article reviews the rationale and evidence supporting preferential use of monotherapy when possible and guidelines for initiating and successfully employing AED monotherapy. Suggested approaches to...
متن کاملMonotherapy trials of new antiepileptic drugs.
A number of clinical trials that test the efficacy and safety of the newer antiepileptic drugs (AEDs) have recently been concluded. Two dose-response trials in inpatients with refractory partial seizures and outpatients with newly diagnosed partial epilepsy established the efficacy of gabapentin as monotherapy. Lamotrigine was found to have efficacy similar to that of phenytoin and carbamazepin...
متن کاملRational conversion from antiepileptic polytherapy to monotherapy.
For patients with epilepsy, the goal of treatment is to achieve seizure freedom with minimal or no adverse events. Around 60%-70% of newly diagnosed patients will achieve this goal with single antiepileptic drug (AED) therapy, and there is universal agreement that prescription of a single agent constitutes best practice for such patients. For the 30%-40% of patients with poorly controlled epile...
متن کاملThe outcome of initiation of antiepileptic drug monotherapy in primary care: a UK database survey.
We describe the incidence of newly treated epilepsy in primary care and patterns of antiepileptic drug prescription, numbers of patients who remain on initial therapy and health service utilisation. Data was collected from 100 general practices that subscribed to the Doctors Independent Network (DIN-LINK) project. Over the study period 1531 patients were identified, equating to an annual incide...
متن کاملEffects of Antiepileptic Drug Monotherapy on One-Carbon Metabolism and DNA Methylation in Patients with Epilepsy
PURPOSE The aim of this study was to compare the serum levels of one-carbon metabolism (OCM) nutrients (e.g., folate, homocysteine and vitamin B12) and peripheral blood DNA methylation in epileptic patients under treatment with antiepileptic drugs (AEDs) and in healthy controls. METHODS In this cross-sectional study, 60 patients with epilepsy who were receiving valproate (VPA) (n = 30) or lam...
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ژورنال
عنوان ژورنال: Epilepsia
سال: 1997
ISSN: 0013-9580,1528-1167
DOI: 10.1111/j.1528-1157.1997.tb04598.x